Endocrine Abstracts

Objective: To evaluate the prevalence of thyroid cancer in patients with suspected thyroid nodule referred from primary care.Methods: Retrospective cohort study which included patients with suspected thyroid nodule referred from primary care to a high-resolution thyroid nodule clinic. Demographic and clinical characteristics were collected, all patients underwent thyroid ultrasound and subsequently, a fine-needle aspiration (FNA) was performed if thyroid...

Introduction: We wanted to analyse the descriptive variables of a series of 1567 thyroidectomy patients between 2010 and 2013 and its association with malignancy in our series.Material and methods: Retrospective, multicentre study done by review of the medical records of 1567 patients who became thyroidectomy between 2010 and 2013 in eight sanitary areas. This is an analysis of clinical and demographic variables.Results: The percen...

Introduction: Congenital adrenal hyperplasia (CAH) is a prevalent disturb in female to male gender identity disorder (GID). However, psychoendocrinology of GID is not yet fully understood.Case Report: A 22-year-old patient(46, XX), was sent from Psychiatry-Sexology to Endocrinology consultation for GID to start hormonal treatment. Self-awareness as a male began at 12-year-old. Menarche at the age of 13 years. At 14-year-old, it was noticed overgrowth of ...

Diabetes insipidus is a disease characterized by the inability to concentrate urine. The common form is central diabetes insipidus (CDI) caused by a lack of AVP after destruction of supraoptic–paraventricular nuclei. Further investigations are needed to establish its cause.: Case reportA 38-year-old woman presented with prompt polyuria–polydipsia. She has been taking contraceptive tablets for 2 years, smoked four to five cigarettes per day....

Introduction: Cutaneous metastization of differentiated thyroid carcinomas is a rare event.Clinical case: MMS, a 69-year-old male was submitted to left hemithyroidectomy+isthmectomy on May 2006 after FNA of a left node revealed follicular tumor. Histology showed Hurthle cell adenoma. The patient maintained irregular follow-up by endocrinologist. In October 2011 he referred the appearance of small bilateral cervical skin nodules. Physical exam showed thre...

Objective: To evaluate possible differences in 24 hours blood pressure (BP) and vascular risk profile (VRP) of normotensive (NT) and untreated hypertensive (UHT) patients with normoglycemia (NG) or Impaired Fasting Glucose (IFG).Design and methods: From 9.812 nondiabetic subjects taken from the Spanish ABPM (Ambulatory Blood Pressure Monitoring) Registry, we compared 24-h BP and VRP differences between patients with NG [n-6,875 (43.3% NT and 56....

In the last years estrogens have emerged as important regulators in male reproductive function. Spermatogenesis depends on the tight control of germ cell apoptosis and several studies indicated estrogens as playing a role in this process. The stem cell factor (SCF), a membrane-bound cytokine, and its receptor (c-kit), and the Fas ligand (FasL)/Fas receptor (FasR) system are powerful mechanisms controlling germ cell proliferation and apoptosis through the direct membrane commun...

Epidemiological studies have shown that plasma SHBG levels correlate with plasma adiponectin levels, both in men and women. To the best of our knowledge there are no reports describing any molecular mechanism by which adiponectin regulates hepatic SHBG production. The aim of the present study is to explore whether adiponectin regulates SHBG production by increasing HNF-4α levels through reducing hepatic lipid content. For this purpose, in vitro studies using huma...

Introduction: Several studies point towards lower testosterone levels (TL) in patients with obesity and/or insulin resistance (IR).Aim: To analyze the influence of anthropometric parameters and IR on TL in obese men and weight-dependent changes after a short-term weight loss program.Methods: Data were collected from a group of male patients, aged 18 to 65, when they attended a first obesity appointment and at reassessment 6 months ...

Context: Acromegaly associated to schizophrenia was firstly reported ~60 years ago and, so far it is unclear whether this association is causal or not.Objective: We report on three new cases and discuss the potential pathophysiological mechanisms of this association.Results: We report two males and one female diagnosed with schizophrenia and treated for several years with antipsychotics who developed acromegaly due to a GH-secretin...